Nrf2 and oxidative stress in liver ischemia/reperfusion injury

R G. Bardallo, A Panisello‐Roselló… - The FEBS …, 2022 - Wiley Online Library
In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …

Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin

GD de Melo, F Lazarini, F Larrous, L Feige… - EMBO molecular …, 2021 - embopress.org
The devastating pandemic due to SARS‐CoV‐2 and the emergence of antigenic variants
that jeopardize the efficacy of current vaccines create an urgent need for a comprehensive …

An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches

J Lee, J Jang, SM Park, SR Yang - International Journal of Molecular …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …

[HTML][HTML] Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

CA Labarrere, GS Kassab - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus
disease 19 (COVID-19) has numerous risk factors leading to severe disease with high …

The good and bad of Nrf2: an update in Cancer and New perspectives in COVID-19

S Emanuele, A Celesia, A D'Anneo… - International Journal of …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known transcription factor best
recognised as one of the main regulators of the oxidative stress response. Beyond playing a …

Vaccination of cancer patients against COVID-19: towards the end of a dilemma

A Mandal, P Singh, A Samaddar, D Singh, M Verma… - Medical Oncology, 2021 - Springer
With the emergence of second wave of COVID-19 infection globally, particularly in India in
March–April 2021, protection by massive vaccination drive has become the need of the …

The hormetic response of heart rate of fish embryos to contaminants–Implications for research and policy

E Agathokleous - Science of The Total Environment, 2022 - Elsevier
Evidence of contaminant-induced hormesis is rapidly accumulating, while the underlying
mechanisms of hormesis are becoming increasingly understood. Recent developments in …

Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor

D Rodrigues, MR Machado, JV Alves… - American Journal …, 2023 - journals.physiology.org
The cytokine storm in SARS-CoV-2 infection contributes to the onset of inflammation and
target-organ damage. The endothelium is a key player in COVID-19 pathophysiology and it …

[HTML][HTML] Transcription factor Nrf2 as a potential therapeutic target for COVID-19

Y Wang, J Ma, Y Jiang - Cell Stress and Chaperones, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) is caused by a novel severe acute
respiratory syndrome (SARS)–like coronavirus (SARS-CoV-2). Critically ill patients with …