Highlights•Overview of challenges, approaches, and opportunities of LC-MS–based
secretomics.•Guidance for unbiased analysis of secreted proteins from cultured …

Theranostics combines diagnostics and therapy in a single multifunctional system.
Multifunctional upconversion luminescent lanthanide-doped nanothermometers for …

Despite an enormous interest in the role of extracellular vesicles, including exosomes, in
cancer and their use as biomarkers for diagnosis, prognosis, drug response and recurrence …

Extracellular vesicles (EVs) contain various bioactive molecules such as DNA, RNA, and
proteins, and play a key role in the regulation of cancer progression. Furthermore, cancer …

The protein corona formed on the surface of a nanoparticle in a biological medium
determines its behavior in vivo. Herein, iron oxide nanoparticles containing the same core …

Cancer cell-derived secretomes have been documented to play critical roles in cancer
progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved …

Extracellular cysteine cathepsins are known to drive cancer progression, but besides
degradation of extracellular matrix proteins little is known about their physiological …

The study of extracellular vesicles (EVs) in cancer progression is a complex and rapidly
evolving field. Whole categories of cellular interactions in cancer which were originally …

Cancer cell-derived extracellular vesicles (EVs) are increasingly being recognized as
genuine invasive structures as they contribute to many aspects of invasion and metastasis …

Purpose: The study of the cancer secretome suggests that a fraction of the intracellular
proteome could play unanticipated roles in the extracellular space during tumorigenesis. A …