Magnetic resonance spectroscopy (MRS) can give information about cellular metabolism in
vivo which is difficult to obtain in other ways. In skeletal muscle, non‐invasive 31 P MRS …

Enormous interest has emerged in the perioperative use of high concentrations of inspired
oxygen in an attempt to increase tissue oxygenation and thereby improve postoperative …

The final steps of the O2 cascade during exercise depend on the product of the
microvascular‐to‐intramyocyte PO 2 P_O_2 difference and muscle O2 diffusing capacity (D …

Key points In vivo skeletal muscle mitochondrial respiratory capacity was determined from
the post‐exercise recovery kinetics of muscle oxygen consumption () measured using near …

Background SRT2104 has been developed as a selective small molecule activator of SIRT1,
a NAD+-dependent deacetylase involved in the regulation of energy homeostasis and the …

Mitochondrial capacity is pivotal to skeletal muscle function and is suggested to decline with
age. However, there is large heterogeneity in current data, possibly due to effect modifiers …

Aging is a progressive process that could disturb metabolic homeostasis in the liver via
ectopic lipid accumulation, oxidative stress, and deterioration of inflammatory response …

Key points Healthy older adults exhibit lower cardiorespiratory fitness () than young in the
absence of any age‐related difference in skeletal muscle mitochondrial capacity, suggesting …

The cardiovascular and skeletal muscle systems are intrinsically interconnected, sharing the
goal of delivering oxygen to metabolically active tissue. Deficiencies within those systems …

Because of the fundamental dependence of mammalian life on adequate mitochondrial
function, the question of how and why mitochondria change in old age is the target of …