Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

All the symptoms and pathology of malaria are caused by the intraerythrocytic stages of the
Plasmodium parasite life cycle. Because Plasmodium parasites cannot replicate outside a …

The global agenda for malaria eradication would benefit from development of a highly
efficacious vaccine that protects against disease and interrupts transmission of Plasmodium …

Some human malaria Plasmodium falciparum parasites, but not others, also cause disease
in Aotus monkeys. To identify the basis for this variation, we crossed two clones that differ in …

The Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175) is a ligand for
merozoite invasion into human erythrocytes that binds to glycophorin A in a sialic acid …

Parasites of the genus Plasmodium have a complex life cycle. They alternate between their
final mosquito host and their intermediate hosts. The parasite can be either extra-or …

Malaria parasites must recognise and invade different cells during their life cycle. The
efficiency with which Plasmodium falciparum invades erythrocytes of all ages is an important …

In the war against Plasmodium, humans have evolved to eliminate or modify proteins on the
erythrocyte surface that serve as receptors for parasite invasion, such as the Duffy blood …

Invasion of erythrocytes by Plasmodium falciparum involves a complex cascade of protein-
protein interactions between parasite ligands and host receptors. The reticulocyte binding …

Malaria remains a highly prevalent disease in more than 90 countries and accounts for at
least 1 million deaths every year. Plasmodium falciparum infection is often associated with a …