The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis
LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of
cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific …
cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific …
TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways
LN Wang, ZT Zhang, L Wang, HX Wei, T Zhang… - Cell death & …, 2022 - nature.com
The pathogenesis of lung cancer, the most common cancer, is complex and unclear, leading
to limited treatment options and poor prognosis. To provide molecular insights into lung …
to limited treatment options and poor prognosis. To provide molecular insights into lung …
[HTML][HTML] DNA damage and repair in the hematopoietic system: DNA damage and repair in the hematopoietic system
N Li, H Chen, J Wang - Acta Biochimica et Biophysica Sinica, 2022 - ncbi.nlm.nih.gov
Although hematopoietic stem cells (HSCs) in the bone marrow are in a state of quiescence,
they harbor the self-renewal capacity and the pluripotency to differentiate into mature blood …
they harbor the self-renewal capacity and the pluripotency to differentiate into mature blood …
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
Impaired ribosome function is the underlying etiology in a group of bone marrow failure
syndromes called ribosomopathies. However, how ribosomes are regulated remains poorly …
syndromes called ribosomopathies. However, how ribosomes are regulated remains poorly …
[HTML][HTML] MYC promotes bone marrow stem cell dysfunction in Fanconi anemia
A Rodríguez, K Zhang, A Färkkilä, J Filiatrault, C Yang… - Cell stem cell, 2021 - cell.com
Bone marrow failure (BMF) in Fanconi anemia (FA) patients results from dysfunctional
hematopoietic stem and progenitor cells (HSPCs). To identify determinants of BMF, we …
hematopoietic stem and progenitor cells (HSPCs). To identify determinants of BMF, we …
SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells
Fanconi anemia (FA) is a hereditary disorder caused by mutations in any 1 of 22 FA genes.
The disease is characterized by hypersensitivity to interstrand crosslink (ICL) inducers such …
The disease is characterized by hypersensitivity to interstrand crosslink (ICL) inducers such …
PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response
X Geng, C Zhang, M Li, J Wang, F Ji, H Feng… - Advanced …, 2022 - Wiley Online Library
The Plk1‐interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase
DNA bridges in mitosis along with a complex of DNA repair proteins. Previous studies show …
DNA bridges in mitosis along with a complex of DNA repair proteins. Previous studies show …
Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress
The prototypic cancer-predisposition disease Fanconi Anemia (FA) is identified by biallelic
mutations in any one of twenty-three FANC genes. Puzzlingly, inactivation of one Fanc gene …
mutations in any one of twenty-three FANC genes. Puzzlingly, inactivation of one Fanc gene …
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes
CS Thom, BF Voight - BMC medical genomics, 2020 - Springer
Background Genetic associations link hematopoietic traits and disease end-points, but most
causal variants and genes underlying these relationships are unknown. Here, we used …
causal variants and genes underlying these relationships are unknown. Here, we used …
LNK promotes the growth and metastasis of triple negative breast cancer via activating JAK/STAT3 and ERK1/2 pathway
J Lv, W Yu, Y Zhang, X Cao, L Han, H Hu… - Cancer cell …, 2020 - Springer
Background LNK adaptor protein is a crucial regulator of normal hematopoiesis, which down-
regulates activated tyrosine kinases at the cell surface resulting in an antitumor effect. To …
regulates activated tyrosine kinases at the cell surface resulting in an antitumor effect. To …