LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of
cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific …

The pathogenesis of lung cancer, the most common cancer, is complex and unclear, leading
to limited treatment options and poor prognosis. To provide molecular insights into lung …

Although hematopoietic stem cells (HSCs) in the bone marrow are in a state of quiescence,
they harbor the self-renewal capacity and the pluripotency to differentiate into mature blood …

Impaired ribosome function is the underlying etiology in a group of bone marrow failure
syndromes called ribosomopathies. However, how ribosomes are regulated remains poorly …

Bone marrow failure (BMF) in Fanconi anemia (FA) patients results from dysfunctional
hematopoietic stem and progenitor cells (HSPCs). To identify determinants of BMF, we …

Fanconi anemia (FA) is a hereditary disorder caused by mutations in any 1 of 22 FA genes.
The disease is characterized by hypersensitivity to interstrand crosslink (ICL) inducers such …

The Plk1‐interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase
DNA bridges in mitosis along with a complex of DNA repair proteins. Previous studies show …

The prototypic cancer-predisposition disease Fanconi Anemia (FA) is identified by biallelic
mutations in any one of twenty-three FANC genes. Puzzlingly, inactivation of one Fanc gene …

Background Genetic associations link hematopoietic traits and disease end-points, but most
causal variants and genes underlying these relationships are unknown. Here, we used …

Background LNK adaptor protein is a crucial regulator of normal hematopoiesis, which down-
regulates activated tyrosine kinases at the cell surface resulting in an antitumor effect. To …