mTORC1 signaling: a double-edged sword in diabetic β cells

A Ardestani, B Lupse, Y Kido, G Leibowitz, K Maedler - Cell Metabolism, 2018 - cell.com
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

[HTML][HTML] Glucosamine potentiates the differentiation of adipose-derived stem cells into glucose-responsive insulin-producing cells

Y Hong, EY Park, D Kim, H Lee, HS Jung… - Annals of Translational …, 2020 - ncbi.nlm.nih.gov
Background Islet transplantation might be a logical strategy to restore insulin secretion for
the treatment of diabetes, however, the scarcity of donors poses an obstacle for such a …

How β cells can smell insulin fragments

A Ardestani, K Maedler - Cell Metabolism, 2022 - cell.com
In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in β cells with
increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes …

[引用][C] CUCURBITACIN ATTENUATES HYPERGLYCEMIA BY INCREASING GLUT2 THROUGH PI3K-PAKT IN THE HEPATOCYTES OF STREPTOZOTOCIN …

GS Banu - 2017