The increasing lifespan in developed countries results in age-associated chronic diseases.
Biological aging is a complex process associated with accumulated cellular damage by …

Cancer is one of the leading causes of death worldwide. Commonly used cancer treatments,
including chemotherapy and radiation therapy, often have side effects and a complete cure …

Summary Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of
γ-secretase, cause familial Alzheimer's disease (fAD). We hypothesized that mutations in …

The controlled in vitro differentiation of human embryonic stem cells (hESCs) and other
pluripotent stem cells provides interesting prospects for generating large numbers of human …

Background Curcumin inhibits the growth of esophageal cancer cell lines; however, the
mechanism of action is not well understood. It is becoming increasingly clear that aberrant …

Background Alzheimer's disease (AD) is a neurodegenerative disorder that causes
progressive memory and cognitive decline during middle to late adult life. The AD brain is …

Glomerular diseases account for 90% of end-stage kidney disease. Podocyte loss is a
common determining factor for the progression toward glomerulosclerosis. Mature …

Stem cells are essential for tissue generation during the development of multicellular
creatures, and for tissue homeostasis in adults. The great therapeutic promise of stem cells …

The endocannabinoid system (ECS) governs and coordinates several physiological
processes through an integrated signaling network, which is responsible for inducing …

Given the rapid growth of engineered and customer products made of silver nanoparticles
(Ag NPs), understanding their biological and toxicological effects on humans is critically …