NK-2 is an antimicrobial peptide derived from helices 3 and 4 of the pore-forming protein of
natural killer cells, NK-lysin. It has potent activities against Gram-negative and Gram-positive …

Host defense peptides (HDP) constitute effector molecules of the innate immune system.
Besides acting against microbia and fungi, they exhibit broad and selective oncolytic activity …

The lipid phosphatase Ship2 represents a drug discovery target for the treatment of different
diseases, including cancer. Its C-terminal sterile alpha motif domain (Ship2-Sam) associates …

Current cancer treatment is frequently compromised by severe adverse effects on healthy
cells and tissues as well as by the increasing burden of (multi‐) drug resistances. Some …

The excessive use of antibiotics is increasingly leading to the formation of resistance, which
will cause into a global crisis. The requirement for potential alternative therapeutics is …

Diese Arbeit beschäftigt sich mit der Testung des antimikrobiellen Peptids NK-2, seinen
Derivaten sowie dem vom Bienengift abstammenden Melittin. Den Anfang der Arbeit bildet …

Antimicrobial peptides (AMPs) have been proposed as promising alternatives to
conventional antibiotics. They are highly selective and efficient bactericidal agents that are …

In dieser Arbeit konnte das Fusionsprotein ONC-DCless-H6-(P)-NK-2-ALK erfolgreich
hergestellt werden. Für den Upstreamprozess wurde zuerst eine Batch-Kultivierung für E …

Die Zahl der antibiotikaresistenten pathogenen Mikroorganismen hat in den vergangenen
Jahren immer weiter zugenommen. Daher liegt der Fokus der aktuellen Forschung unter …

While there is no doubt that tax evasion is wide-spread in developing countries, exact
measures of its extent are difficult to obtain because, by definition, tax evasion is hidden …