Various features, components, and functions of the immune system present daily variations.
Immunocompetent cell counts and cytokine levels present variations according to the time of …

There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of …

The conjunctiva is a goblet cell rich mucosal tissue. Goblet cells are supported by tear
growth factors and IL-13 produced by resident immune cells. Goblet cell secretions are …

The use of non-human primate models is required to understand the ageing process and
evaluate new therapies against age-associated pathologies. The present article summarizes …

Deletion of the core clock gene, Bmal1, ablates circadian rhythms and accelerates aging,
leading to cognitive deficits and tissue atrophy (eg, skeletal muscle)(Kondratov et al., 2006 …

Circadian rhythms are ubiquitous attributes across living organisms and allow the
coordination of internal biological functions with optimal phases of the environment …

In this review we describe how Trypanosoma brucei brucei, a rodent pathogenic strain of
African trypanosomes, can invade the nervous system, first by localization to the choroid …

Circadian clocks serve to impose a near-24-h temporal architecture on an organism's
physiology, metabolism, and behavior. In mammals, the suprachiasmatic nucleus (SCN) of …

Circadian rhythms, which measure time on a scale of 24 h, are genetically generated by the
circadian clock, which plays a crucial role in the regulation of almost every physiological and …

From circulation to digestion to excretion, a circadian clock synchronizes most aspects of
mammalian physiology with the solar day. During normal ageing, this daily coordination …