Functions of N6-methyladenosine and its role in cancer
L He, H Li, A Wu, Y Peng, G Shu, G Yin - Molecular cancer, 2019 - Springer
Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer
B Zhang, Q Wu, B Li, D Wang, L Wang, YL Zhou - Molecular cancer, 2020 - Springer
Background The epigenetic regulation of immune response has been demonstrated in
recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m 6 A) …
recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m 6 A) …
N6-Methyladenosine RNA modification in the tumor immune microenvironment: novel implications for immunotherapy
L Guo, H Yang, C Zhou, Y Shi, L Huang… - Frontiers in …, 2021 - frontiersin.org
N6-methyladenosine (m6A) methylation is one of the most common modifications of RNA in
eukaryotic cells, and is mainly regulated by m6A methyltransferases (writers), m6A …
eukaryotic cells, and is mainly regulated by m6A methyltransferases (writers), m6A …
METTL1‐m7G‐EGFR/EFEMP1 axis promotes the bladder cancer development
X Ying, B Liu, Z Yuan, Y Huang, C Chen… - Clinical and …, 2021 - Wiley Online Library
Background The posttranscriptional modifications of transfer RNA (tRNA) are critical for all
aspects of the tRNA function and have been implicated in the tumourigenesis and …
aspects of the tRNA function and have been implicated in the tumourigenesis and …
Molecular characterization and clinical relevance of m6A regulators across 33 cancer types
The methylation of N 6 adenosine (m 6 A) plays a critical role in diverse biological
processes. However, knowledge regarding the reconstitution of m 6 A across cancer types is …
processes. However, knowledge regarding the reconstitution of m 6 A across cancer types is …
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
Y Hu, C Chen, X Tong, S Chen, X Hu, B Pan… - Cell death & …, 2021 - nature.com
Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma
B Chen, W Jiang, Y Huang, J Zhang, P Yu, L Wu… - Oncogene, 2022 - nature.com
Abstract Treatment selections are very limited for patients with advanced nasopharyngeal
carcinoma (NPC) experiencing disease progression. Uncovering mechanisms underlying …
carcinoma (NPC) experiencing disease progression. Uncovering mechanisms underlying …
[HTML][HTML] m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation
J Li, L Zhu, Y Shi, J Liu, L Lin… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) acts as the most common mRNA modification in
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …
[HTML][HTML] Expression patterns and prognostic value of m6A-related genes in colorectal cancer
X Liu, L Liu, Z Dong, J Li, Y Yu, X Chen… - American journal of …, 2019 - ncbi.nlm.nih.gov
Colorectal cancer (CRC), including colon adenocarcinoma (COAD) and rectal
adenocarcinoma (READ), is one of the most prevalent malignancies worldwide. N 6 …
adenocarcinoma (READ), is one of the most prevalent malignancies worldwide. N 6 …
3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line
A Malacrida, M Rivara, A Di Domizio, G Cislaghi… - Bioorganic & Medicinal …, 2020 - Elsevier
Abstract The imidazobenzoxazin-5-thione MV1035, synthesized as a new sodium channel
blocker, has been tested on tumoral cells that differ for origin and for expressed Na V pool …
blocker, has been tested on tumoral cells that differ for origin and for expressed Na V pool …