Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …

Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

Metformin, a drug widely used for treating diabetes, can prolong the lifespan in several
species. Metformin also has the promise to slow down age‐related cognitive impairment …

Type 2 diabetes mellitus (T2DM) is a complex, chronic and progressive metabolic disease,
which is characterized by relative insulin deficiency, insulin resistance, and high glucose …

Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

The prevalence of obesity is growing and now includes at least one-third of the adult
population in the United States. As obesity and dementia rates reach epidemic proportions …

Metformin as a first-line drug for type 2 diabetes mellitus (T2DM) treatment is widely studied.
Metformin can reduce liver glucose output and improve insulin resistance. Recent evidence …