Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

The overall lifetime risk of heart failure (HF) is similar between men and women, however,
there are marked sex differences in the landscape of this condition that are both important …

“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Importance Frailty is a common geriatric syndrome of significant public health importance,
yet there is limited understanding of the risk of frailty development at a population level …

The gut microbiota changes with age, but it is not clear to what degree these changes are
due to physiologic changes, age-associated inflammation or immunosenescence, diet …

Background The fraily index is a useful proxy measure of accelerated biological ageing and
in estimating all-cause and cause-specific mortality in older individuals in European and US …

Background Despite a non-specific nature of self-rated health (SRH), it seems to be a strong
predictor of mortality. The aim of this study is to assess the association of SRH and objective …

Objective To systematically assess the prevalence of frailty, including prefrailty, stratified
prevalence according to frailty criteria, gender, age, and region, and the risk factors for frailty …

Frailty describes an individual's vulnerability to adverse health outcomes and is a useful
construct that assists health professionals to understand the heterogeneity of the ageing …

Frailty can be viewed as a state of physiological decline that increases susceptibility to
adverse health outcomes. This loss of physiological reserve means that even small stressors …