CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …

Vector-borne illnesses comprise a significant portion of human maladies, representing 17%
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …

The impact of T helper (Th) 1 versus Th2 immunity on intracellular infections is attributed to
classical versus alternative activation of macrophages leading to resistance or susceptibility …

The trypanosomatid (protozoan) parasites Trypanosoma cruzi and Leishmania spp. are
causative agents of Chagas disease and Leishmaniasis, respectively. They display high …

In 2020, the WHO established the road map for neglected tropical diseases 2021–2030,
which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas …

Fatty acids have received growing interest in Leishmania biology with the characterization of
the enzymes allowing the complete fatty acid synthesis of this trypanosomatid parasite. This …

Intracellular phagosomal pathogens represent a formidable challenge for innate immune
cells, as, paradoxically, these phagocytic cells can act as both host cells that support …

The innate immune system is the body's first line of defense against pathogens and its
protection against infectious diseases. On the surface of host myeloid cells, Toll-like receptor …

Introduction Pathogenesis of cutaneous leishmaniases involves parasite growth, persistent
inflammation, and likely participation of lipoproteins (LP). The cholesteryl ester transfer …

Hampering‐surface presentation of immunogenic peptides by class I/II MHCs is a key
strategy opted by several intracellular protozoan pathogens including Leishmania to escape …