Endogenous microRNA sponges: evidence and controversy

DW Thomson, ME Dinger - Nature Reviews Genetics, 2016 - nature.com
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …

Prediction of miRNA targets

A Oulas, N Karathanasis, A Louloupi… - RNA …, 2015 - Springer
Computational methods for miRNA target prediction are currently undergoing extensive
review and evaluation. There is still a great need for improvement of these tools and …

DNMT3A epigenetically regulates key microRNAs involved in epithelial-to-mesenchymal transition in prostate cancer

M Mancini, M Grasso, L Muccillo, F Babbio… - …, 2021 - academic.oup.com
Epithelial-to-mesenchymal transition (EMT) is involved in prostate cancer (PCa) metastatic
progression, and its plasticity suggests epigenetic implications. Deregulation of DNA …

[HTML][HTML] β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) …

S Ibrahim, M Johnson, CH Stephens, J Xu, R Moore… - Molecular …, 2021 - Elsevier
Abstract Objective β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but
it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the …

Changes in expression of microRNA potentially targeting key regulators of lipid metabolism in primary gilthead sea bream hepatocytes exposed to phthalates or flame …

P Cocci, G Mosconi, FA Palermo - Aquatic Toxicology, 2019 - Elsevier
Highlights•We analyzed the effects of DiDP/TMCP exposure on the expression levels of 3
miRNAs.•DiDP/TMCP exposure led to a decrease in the expression of each …

Small RNA targets: advances in prediction tools and high-throughput profiling

K Grešová, P Alexiou, IC Giassa - Biology, 2022 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are a category of small RNAs (sRNAs) that have
been found to regulate gene expression. Through the mediation of proteins from the …

MicroRNA target prediction tools for animals: Where we are at and where we are going to-A systematic review

RMMW Feitosa, P Prieto-Oliveira, H Brentani… - … Biology and Chemistry, 2022 - Elsevier
MicroRNAs (miRNAs) are non-coding RNAs containing 19–26 nucleotides, and they directly
regulate the translation of mRNAs by binding to them. MiRNAs participate in various …

Identifying interaction clusters for miRNA and mRNA pairs in TCGA network

X Dai, L Ding, H Liu, Z Xu, H Jiang, SK Handelman… - Genes, 2019 - mdpi.com
Existing methods often fail to recognize the conversions for the biological roles of the pairs of
genes and microRNAs (miRNAs) between the tumor and normal samples. We have …

MiRduplexSVM: a high-performing miRNA-duplex prediction and evaluation methodology

N Karathanasis, I Tsamardinos, P Poirazi - PloS one, 2015 - journals.plos.org
We address the problem of predicting the position of a miRNA duplex on a microRNA
hairpin via the development and application of a novel SVM-based methodology. Our …

Circulating microRNA trafficking and regulation: computational principles and practice

J Cui, J Shu - Briefings in bioinformatics, 2020 - academic.oup.com
Rapid advances in genomics discovery tools and a growing realization of microRNA's
implication in intercellular communication have led to a proliferation of studies of circulating …