Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis
Infection by Schistosoma parasites culminates in a chronic granulomatous disease
characterized by intense tissue fibrosis. Along the course of schistosomiasis, diverse …
characterized by intense tissue fibrosis. Along the course of schistosomiasis, diverse …
The genetics of human schistosomiasis infection intensity and liver disease: A review
EM Mewamba, OA Nyangiri, HA Noyes… - Frontiers in …, 2021 - frontiersin.org
Schistosomiasis remains the fourth most prevalent parasitic disease affecting over 200
million people worldwide. Control efforts have focussed on the disruption of the life cycle …
million people worldwide. Control efforts have focussed on the disruption of the life cycle …
Association between polymorphisms of IL4, IL13, IL10, STAT6 and IFNG genes, cytokines and immunoglobulin E levels with high burden of Schistosoma mansoni in …
EM Mewamba, H Noyes, AAZ Tiofack… - Infection, Genetics and …, 2023 - Elsevier
Eliminating schistosomiasis as a public health problem by 2030 requires a better
understanding of the disease transmission, especially the asymmetric distribution of worm …
understanding of the disease transmission, especially the asymmetric distribution of worm …
Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda
Background Individuals genetically susceptible to high schistosomiasis worm burden may
contribute disproportionately to transmission and could be prioritized for control. Identifying …
contribute disproportionately to transmission and could be prioritized for control. Identifying …
Interleukin-13 rs1800925/-1112C/T promoter single nucleotide polymorphism variant linked to anti-schistosomiasis in adult males in Murehwa District, Zimbabwe
ET Choto, T Mduluza, MJ Chimbari - Plos one, 2021 - journals.plos.org
Background Chronic schistosomiasis is predominantly induced through up-regulation of
inflammatory cytokines such as interleukin (IL)-13. IL-13 may contribute to the disease …
inflammatory cytokines such as interleukin (IL)-13. IL-13 may contribute to the disease …
C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum‐Infected Mice
M Duan, Y Yang, S Peng, X Liu, J Zhong… - Journal of …, 2019 - Wiley Online Library
CCAAT/enhancer‐binding homologous protein (CHOP), a transcriptional regulator induced
by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress‐mediated …
by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress‐mediated …
Severity of Schistosoma haematobium co-infection with malaria in school-children is potentially modulated by host CD14 gene variants
MA Oboh-Imafidon, SM Torbit, S Jacob… - BMC Research …, 2023 - Springer
Objective Schistosomiasis remains a chronic disease of global importance, especially in
many rural areas of the world where co-infection with Plasmodium falciparum is common. It …
many rural areas of the world where co-infection with Plasmodium falciparum is common. It …
Interleukin-4 signaling plays a major role in urogenital schistosomiasis-associated bladder pathogenesis
EC Mbanefo, CL Fu, CP Ho, L Le, K Ishida… - Infection and …, 2020 - Am Soc Microbiol
ABSTRACT Interleukin-4 (IL-4) is crucial in many helminth infections, but its role in
urogenital schistosomiasis, infection with Schistosoma haematobium worms, remains poorly …
urogenital schistosomiasis, infection with Schistosoma haematobium worms, remains poorly …
Frequency distribution of cytokine and associated transcription factor single nucleotide polymorphisms in Zimbabweans: Impact on schistosome infection and cytokine …
AJ Hanton, F Scott, K Stenzel, N Nausch… - PLoS Neglected …, 2022 - journals.plos.org
Cytokines mediate T-helper (TH) responses that are crucial for determining the course of
infection and disease. The expression of cytokines is regulated by transcription factors (TFs) …
infection and disease. The expression of cytokines is regulated by transcription factors (TFs) …
[HTML][HTML] Candidate gene family-based and case-control studies of susceptibility to high Schistosoma mansoni worm burden in African children: a protocol
OA Nyangiri, SA Edwige, M Koffi, E Mewamba… - AAS open …, 2021 - ncbi.nlm.nih.gov
Background: Approximately 25% of the risk of Schistosoma mansoni is associated with host
genetic variation. We will test 24 candidate genes, mainly in the T h 2 and T h 17 pathways …
genetic variation. We will test 24 candidate genes, mainly in the T h 2 and T h 17 pathways …