Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis

COS Souza, LG Gardinassi, V Rodrigues… - Frontiers in …, 2020 - frontiersin.org
Infection by Schistosoma parasites culminates in a chronic granulomatous disease
characterized by intense tissue fibrosis. Along the course of schistosomiasis, diverse …

The genetics of human schistosomiasis infection intensity and liver disease: A review

EM Mewamba, OA Nyangiri, HA Noyes… - Frontiers in …, 2021 - frontiersin.org
Schistosomiasis remains the fourth most prevalent parasitic disease affecting over 200
million people worldwide. Control efforts have focussed on the disruption of the life cycle …

Association between polymorphisms of IL4, IL13, IL10, STAT6 and IFNG genes, cytokines and immunoglobulin E levels with high burden of Schistosoma mansoni in …

EM Mewamba, H Noyes, AAZ Tiofack… - Infection, Genetics and …, 2023 - Elsevier
Eliminating schistosomiasis as a public health problem by 2030 requires a better
understanding of the disease transmission, especially the asymmetric distribution of worm …

Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda

OA Nyangiri, J Mulindwa, J Namulondo… - PLOS Neglected …, 2023 - journals.plos.org
Background Individuals genetically susceptible to high schistosomiasis worm burden may
contribute disproportionately to transmission and could be prioritized for control. Identifying …

Interleukin-13 rs1800925/-1112C/T promoter single nucleotide polymorphism variant linked to anti-schistosomiasis in adult males in Murehwa District, Zimbabwe

ET Choto, T Mduluza, MJ Chimbari - Plos one, 2021 - journals.plos.org
Background Chronic schistosomiasis is predominantly induced through up-regulation of
inflammatory cytokines such as interleukin (IL)-13. IL-13 may contribute to the disease …

C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum‐Infected Mice

M Duan, Y Yang, S Peng, X Liu, J Zhong… - Journal of …, 2019 - Wiley Online Library
CCAAT/enhancer‐binding homologous protein (CHOP), a transcriptional regulator induced
by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress‐mediated …

Severity of Schistosoma haematobium co-infection with malaria in school-children is potentially modulated by host CD14 gene variants

MA Oboh-Imafidon, SM Torbit, S Jacob… - BMC Research …, 2023 - Springer
Objective Schistosomiasis remains a chronic disease of global importance, especially in
many rural areas of the world where co-infection with Plasmodium falciparum is common. It …

Interleukin-4 signaling plays a major role in urogenital schistosomiasis-associated bladder pathogenesis

EC Mbanefo, CL Fu, CP Ho, L Le, K Ishida… - Infection and …, 2020 - Am Soc Microbiol
ABSTRACT Interleukin-4 (IL-4) is crucial in many helminth infections, but its role in
urogenital schistosomiasis, infection with Schistosoma haematobium worms, remains poorly …

Frequency distribution of cytokine and associated transcription factor single nucleotide polymorphisms in Zimbabweans: Impact on schistosome infection and cytokine …

AJ Hanton, F Scott, K Stenzel, N Nausch… - PLoS Neglected …, 2022 - journals.plos.org
Cytokines mediate T-helper (TH) responses that are crucial for determining the course of
infection and disease. The expression of cytokines is regulated by transcription factors (TFs) …

[HTML][HTML] Candidate gene family-based and case-control studies of susceptibility to high Schistosoma mansoni worm burden in African children: a protocol

OA Nyangiri, SA Edwige, M Koffi, E Mewamba… - AAS open …, 2021 - ncbi.nlm.nih.gov
Background: Approximately 25% of the risk of Schistosoma mansoni is associated with host
genetic variation. We will test 24 candidate genes, mainly in the T h 2 and T h 17 pathways …