Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

Circadian rhythms (Nobel prize for Medicine 2017) regulate, under action of biological
clocks located both at the level of central nervous system and inside peripheral cells, several …

Background High dose intravenous glucocorticoid (ivGC) therapy is the first line treatment in
moderate to severe Graves' ophthalmopathy (GO) and is associated with a clinical response …

Vascular inflammation is present in many cardiovascular diseases, and exogenous
glucocorticoids have traditionally been used as a therapy to suppress inflammation …

The epigenome may be an important interface between exposure to environmental
contaminants and adverse outcome on human health. Many environmental pollutants …

Extracellular signals are transmitted through kinase cascades to modulate gene expression,
but it remains unclear how epigenetic changes regulate this response. Here, we provide …

DNA G-quadruplex is a non-canonical secondary structure that could epigenetically regulate
gene expression. To investigate the regulating role of G-quadruplex, we devised an …

Background Perinatal depression (PD) is one of the most common complications of
pregnancy, and timely diagnosis and treatment are still challenging in China due to the …

Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …

Background Circadian disruption is an emerging driver of breast cancer (BCa), with
epidemiological studies linking shift work and chronic jet lag to increased BCa risk. Indeed …