Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches

MS Uddin, A Al Mamun, BS Alghamdi, D Tewari… - Seminars in cancer …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Role of notch signaling pathway in glioblastoma pathogenesis

R Bazzoni, A Bentivegna - Cancers, 2019 - mdpi.com
Notch signaling is an evolutionarily conserved pathway that regulates important biological
processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation …

[HTML][HTML] Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?

PF Ledur, GR Onzi, H Zong, G Lenz - Oncotarget, 2017 - ncbi.nlm.nih.gov
In cancer research, the use of established cell lines has gradually been replaced by primary
cell cultures due to their better representation of in vivo cancer cell behaviors. However, a …

Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression

CT Meisel, C Porcheri, TA Mitsiadis - Cells, 2020 - mdpi.com
The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate
decisions in both embryonic and adult life. Several aspects of stem cell maintenance are …

Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB (p65 …

L Hai, C Zhang, T Li, X Zhou, B Liu, S Li, M Zhu… - Cell death & …, 2018 - nature.com
Glioblastomas (GBMs) are the most prevalent and devastating primary intracranial
malignancies and have extensive heterogeneity. Notch1 signaling is a more complex …

Research progress on the regulation mechanism of key signal pathways affecting the prognosis of glioma

H Wu, M Wei, Y Li, Q Ma, H Zhang - Frontiers in Molecular …, 2022 - frontiersin.org
As is known to all, glioma, a global difficult problem, has a high malignant degree, high
recurrence rate and poor prognosis. We analyzed and summarized signal pathway of the …

Signaling pathways and mesenchymal transition in pediatric high-grade glioma

MH Meel, SA Schaper, GJL Kaspers… - Cellular and Molecular …, 2018 - Springer
Pediatric high-grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPG), are
the most lethal types of cancer in children. In recent years, it has become evident that these …

The Evolving Roles of Bacopa monnieri as Potential Anti-Cancer Agent: A Review

S Ghosh, R Khanam, A Acharya Chowdhury - Nutrition and Cancer, 2021 - Taylor & Francis
The intermingled interrelationship of Bacopa monnieri and human health dates backs to the
ancient times in the history of ayurveda making the plant an enriched source of alternative …

Transcriptional control of brain tumor stem cells by a carbohydrate binding protein

A Sharanek, A Burban, A Hernandez-Corchado… - Cell reports, 2021 - cell.com
Brain tumor stem cells (BTSCs) and intratumoral heterogeneity represent major challenges
in glioblastoma therapy. Here, we report that the LGALS1 gene, encoding the carbohydrate …

Biogenic silver/silver chloride nanoparticles inhibit human glioblastoma stem cells growth in vitro and Ehrlich ascites carcinoma cell growth in vivo

SR Kabir, Z Dai, M Nurujjaman, X Cui… - Journal of Cellular …, 2020 - Wiley Online Library
The importance of biogenic silver/silver chloride nanoparticles has become increasing day
by day. In the present study, silver/silver chloride nanoparticles (Ag/AgCl‐NPs) were …