EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
E Eskilsson, GV Røsland, G Solecki, Q Wang… - Neuro …, 2018 - academic.oup.com
Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …
[HTML][HTML] High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
R Stupp, M Brada, MJ Van Den Bent… - Annals of …, 2014 - annalsofoncology.org
The yearly incidence of malignant glioma is∼ 3–5/100 000 with a slight predominance in
males. Malignant glioma may develop at all ages, with the peak incidence being in the fifth …
males. Malignant glioma may develop at all ages, with the peak incidence being in the fifth …
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA
DA Nathanson, B Gini, J Mottahedeh, K Visnyei… - Science, 2014 - science.org
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying
mechanisms are not understood. Single-cell analyses of patient-derived models and clinical …
mechanisms are not understood. Single-cell analyses of patient-derived models and clinical …
Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide
K Messaoudi, A Clavreul, F Lagarce - Drug discovery today, 2015 - Elsevier
Highlights•Temozolomide resistance can be induced by glioblastoma cells.•Resistance to
temozolomide is caused by multiple mechanisms.•Different resistance pathways exist in …
temozolomide is caused by multiple mechanisms.•Different resistance pathways exist in …
Differential sensitivity of glioma-versus lung cancer–specific EGFR mutations to EGFR kinase inhibitors
Activation of the epidermal growth factor receptor (EGFR) in glioblastoma (GBM) occurs
through mutations or deletions in the extracellular (EC) domain. Unlike lung cancers with …
through mutations or deletions in the extracellular (EC) domain. Unlike lung cancers with …
EGFR as a clinical marker in glioblastomas and other gliomas
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …
[HTML][HTML] The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma
X Liu, X Chen, L Shi, Q Shan, Q Cao, C Yue… - Journal of Experimental …, 2019 - Springer
Background Glioblastoma (GBM) is a fatal brain tumor, lacking effective treatment.
Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM …
Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM …
The multiple roles of amphiregulin in human cancer
Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR).
AREG plays a central role in mammary gland development and branching morphogenesis …
AREG plays a central role in mammary gland development and branching morphogenesis …
[HTML][HTML] How cancer cells dictate their microenvironment: present roles of extracellular vesicles
Y Naito, Y Yoshioka, Y Yamamoto, T Ochiya - Cellular and Molecular Life …, 2017 - Springer
Intercellular communication plays an important role in cancer initiation and progression
through secretory molecules, including growth factors and cytokines. Recent advances have …
through secretory molecules, including growth factors and cytokines. Recent advances have …