Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

The linker histone H1 family members are a key component of chromatin and bind to the
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …

The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human
cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

The sirtuins are a highly conserved family of NAD+-dependent enzymes that regulate
lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation
is not completely understood. We now show that the microRNA miR-34a regulates silent …

Cancer cells simultaneously harbor global losses and gains in DNA methylation. We
demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits …