Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …

Chickpea is an important leguminous crop with potential to provide dietary proteins to both
humans and animals. It also ameliorates soil nitrogen through biological nitrogen fixation …

Summary The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of
a method to map it at single-base resolution on a genome-wide scale. Affinity purification …

Next-generation sequencing (NGS) technologies using DNA, RNA, or methylation
sequencing have impacted enormously on the life sciences. NGS is the choice for large …

The revolution in cancer research can be summed up in a single sentence: cancer is, in
essence, a genetic disease. In the last decade, many important genes responsible for the …

Bisulfite conversion of genomic DNA combined with next-generation sequencing (BS-seq) is
widely used to measure the methylation state of a whole genome, the methylome, at single …

Colorectal cancer (CRC) is a common malignancy and the fourth leading cause of cancer
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …

Platinum drugs are extensively used in the clinic to treat cancer, often leading to a palliative
response rather than a cure. While DNA is considered to be the primary target of platinum …

Single-cell RNA sequencing methods have led to improved understanding of the
heterogeneity and transcriptomic states present in complex biological systems. Recently, the …

The cell surface is the platform for presentation of biochemical signals that are required for
intercellular communication. Their profile necessarily needs to be responsive to internal and …