In this review we describe major contributions of light and electron microscopic approaches
to the present understanding of functional nuclear architecture. The large gap of knowledge …

Genomic DNA in eukaryotic cells is basically divided into chromosomes, each consisting of
a single huge nucleosomal fiber. It is now clear that chromatin structure and dynamics play a …

Background Local higher-order chromatin structure, dynamics and composition of the DNA
are known to determine double-strand break frequencies and the efficiency of repair …

The organization of interphase chromosomes in chromosome territories (CTs) was first
proposed more than one hundred years ago. The introduction of increasingly sophisticated …

Combination of next-generation DNA sequencing, single nucleotide polymorphism array
analyses and bioinformatics has revealed the striking phenomenon of chromothripsis …

Numerous studies indicate that the genome of higher eukaryotes is organized into distinct
chromosome territories and that the 3‐D arrangement of these territories may be closely …

Impaired DSB repair has been implicated as a molecular mechanism contributing to the
accelerating aging phenotype in Hutchinson-Gilford progeria syndrome (HGPS), but neither …

Chromothripsis (chromosome shattering) has been described as complex rearrangements
affecting single chromosome (s) in one catastrophic event. The chromosomes would be …

DNA double strand breaks (DSBs) are ultimate lesions for the formation of chromosomal
aberrations (CAs). The formation of CAs is dependent on many factors; some of these are …

The formation of diverse chromosomal aberrations following irradiation and the variability in
radiosensitivity at different cell-cycle stages remain a long standing controversy, probably …