Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …

Babesia are tick-transmitted hemoprotozooans that infect mammals and birds, and which
are acknowledged for their major impact on farm and pet animal health and associated …

Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are
expanded in Plasmodium falciparum–infected patients. Although previous studies …

The phylum Apicomplexa comprises human pathogens such as Plasmodium but is also an
under-explored hotspot of evolutionary diversity central to understanding the origins of …

Apicomplexans are a major lineage of parasites, including causative agents of malaria and
toxoplasmosis. How such highly adapted parasites evolved from free-living ancestors is …

Parasites of the phylum Apicomplexa cause diseases that impact global health and
economy. These unicellular eukaryotes possess a relict plastid, the apicoplast, which is an …