Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous
system. The microglial production of immune factors is believed to play an important role in …

Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

Retinal ischemia is a common cause of visual impairment and blindness. At the cellular
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …

Dying cells stimulate inflammation, and this response is thought to contribute to the
pathogenesis of many diseases. Very little has been known, however, about how cell death …

Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal
ischemia in rodents. We examined whether minocycline reduces excitotoxicity in primary …

Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia,
exerting either deleterious effects on the progression of tissue damage or beneficial roles …

1. Stroke is the neurological evidence of a critical reduction of cerebral blood flow in a
circumscribed part of the brain, resulting from the sudden or gradually progressing …

The cytokine interleukin-1 (IL-1) has been strongly implicated in the pathogenesis of
ischemic brain damage. Evidence to date suggests that the major form of IL-1 contributing to …

Abstract The cytokine interleukin 1 (IL-1) has diverse actions in the brain. In normal brain the
IL-1 system is expressed at low levels and is upregulated rapidly in response to local or …

Cerebral ischemia is accompanied by a marked inflammatory reaction that is initiated by
ischemia-induced expression of cytokines, adhesion molecules, and other inflammatory …