The role of key residues in structure, function, and stability of cytochrome-c
Abstract Cytochrome-c (cyt-c), a multi-functional protein, plays a significant role in the
electron transport chain, and thus is indispensable in the energy-production process …
electron transport chain, and thus is indispensable in the energy-production process …
Pre-molten, wet, and dry molten globules en route to the functional state of proteins
MN Gupta, VN Uversky - International Journal of Molecular Sciences, 2023 - mdpi.com
Transitions between the unfolded and native states of the ordered globular proteins are
accompanied by the accumulation of several intermediates, such as pre-molten globules …
accompanied by the accumulation of several intermediates, such as pre-molten globules …
Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches
One of the significant proteins that have attracted research groups due to virtue of being a
potent selective anticancer drug target and property of triggering apoptosis upon release in …
potent selective anticancer drug target and property of triggering apoptosis upon release in …
Chitinase from Thermomyces lanuginosus SSBP and its biotechnological applications
Chitinases are ubiquitous class of extracellular enzymes, which have gained attention in the
past few years due to their wide biotechnological applications. The effectiveness of …
past few years due to their wide biotechnological applications. The effectiveness of …
First evidence of formation of pre-molten globule state in myoglobin: A macromolecular crowding approach towards protein folding in vivo
Myoglobin is known to show formation of intermediate states under various environmental
conditions, in spite of that, this is the first evidence of formation pre-molten globule (PMG) in …
conditions, in spite of that, this is the first evidence of formation pre-molten globule (PMG) in …
Structural characterization of MG and pre-MG states of proteins by MD simulations, NMR, and other techniques
Almost all proteins fold via a number of partially structured intermediates such as molten
globule (MG) and pre-molten globule states. Understanding the structure of these …
globule (MG) and pre-molten globule states. Understanding the structure of these …
Effect of pH on the structure and stability of irisin, a multifunctional protein: Multispectroscopic and molecular dynamics simulation approach
Irisin is a potential therapeutic agent to prevent or treat various metabolic-related disorders
and neurodegenerative diseases viz. Alzheimer's disease (AD). In this study, we have …
and neurodegenerative diseases viz. Alzheimer's disease (AD). In this study, we have …
Formation of molten globule state in horse heart cytochrome c under physiological conditions: Importance of soft interactions and spectroscopic approach in crowded …
To understand protein folding problem under physiological condition, usually taken as dilute
aqueous buffer at pH 7.0 and 25° C, knowledge of properties of folding intermediates is …
aqueous buffer at pH 7.0 and 25° C, knowledge of properties of folding intermediates is …
Mechanistic insights into the urea-induced denaturation of human sphingosine kinase 1
Abstract Sphingosine kinase 1 (SphK1) plays a significant role in various cellular processes,
including cell proliferation, apoptosis, and angiogenesis. SphK1 is considered as an …
including cell proliferation, apoptosis, and angiogenesis. SphK1 is considered as an …
Ubiquitin-associated domain of MARK4 provides stability at physiological pH
Microtubule affinity regulating Kinase 4 (MARK4) belongs to the family of AMP-activated
protein kinase. It phosphorylates microtubule associated proteins at specific sites (Serine in …
protein kinase. It phosphorylates microtubule associated proteins at specific sites (Serine in …