Schizophrenia is frequently characterized as a disorder of brain connectivity. Neuroimaging
has played a central role in supporting this view, with nearly two decades of research …

Context Antipsychotic treatment is the first-line treatment option for schizophrenia. Individual
studies suggested they can significantly affect brain structure and account for progressive …

Resting-state fMRI (RS-fMRI) has been drawing more and more attention in recent years.
However, a publicly available, systematically integrated and easy-to-use tool for RS-fMRI …

Schizophrenia (SZ) and bipolar disorder (BP) share significant overlap in clinical symptoms,
brain characteristics, and risk genes, and both are associated with dysconnectivity among …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Unlike neurologic conditions, such as brain tumors, dementia, and stroke, the neural
mechanisms for all psychiatric disorders remain unclear. A large body of research obtained …

Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious …

Affective empathy (AE) is distinguished clinically and neurally from cognitive empathy (CE).
While AE is selectively disrupted in psychopathy, autism is associated with deficits in CE …

Structure and function in the human brain are closely related. At the onset of psychosis,
brain imaging studies have identified robust changes in brain function and structure, but no …

Background Schizophrenia is a highly disabling psychiatric disorder characterized by a
range of positive “psychosis” symptoms. However, the neurobiology of psychosis and …