Revealing neuronal function through microelectrode array recordings

MEJ Obien, K Deligkaris, T Bullmann… - Frontiers in …, 2015 - frontiersin.org
Microelectrode arrays and microprobes have been widely utilized to measure neuronal
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …

Multi-electrode array technologies for neuroscience and cardiology

ME Spira, A Hai - Nature nanotechnology, 2013 - nature.com
At present, the prime methodology for studying neuronal circuit-connectivity, physiology and
pathology under in vitro or in vivo conditions is by using substrate-integrated microelectrode …

Transparent, conformable, active multielectrode array using organic electrochemical transistors

W Lee, D Kim, N Matsuhisa… - Proceedings of the …, 2017 - National Acad Sciences
Mechanically flexible active multielectrode arrays (MEA) have been developed for local
signal amplification and high spatial resolution. However, their opaqueness limited optical …

Neurotechnologies for human cognitive augmentation: current state of the art and future prospects

C Cinel, D Valeriani, R Poli - Frontiers in human neuroscience, 2019 - frontiersin.org
Recent advances in neuroscience have paved the way to innovative applications that
cognitively augment and enhance humans in a variety of contexts. This paper aims at …

NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury

Z Yang, A Zhang, H Duan, S Zhang… - Proceedings of the …, 2015 - National Acad Sciences
Neural stem cells (NSCs) in the adult mammalian central nervous system (CNS) hold the
key to neural regeneration through proper activation, differentiation, and maturation, to …

Materials chemistry of neural interface technologies and recent advances in three-dimensional systems

Y Park, TS Chung, G Lee, JA Rogers - Chemical Reviews, 2021 - ACS Publications
Advances in materials chemistry and engineering serve as the basis for multifunctional
neural interfaces that span length scales from individual neurons to neural networks, neural …

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

J Dunlop, M Bowlby, R Peri, D Vasilyev… - Nature reviews Drug …, 2008 - nature.com
Ion channels represent highly attractive targets for drug discovery and are implicated in a
diverse range of disorders, in particular in the central nervous and cardiovascular systems …

Integration of cell culture and microfabrication technology

TH Park, ML Shuler - Biotechnology progress, 2003 - Wiley Online Library
Recent progress in cell culture and microfabrication technologies has contributed to the
development of cell‐based biosensors for the functional characterization and detection of …

Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease

CC Liu, CW Tsai, F Deak, J Rogers, M Penuliar… - Neuron, 2014 - cell.com
Alzheimer's disease (AD) is an age-related neurological disorder characterized by synaptic
loss and dementia. The low-density lipoprotein receptor-related protein 6 (LRP6) is an …

A three-dimensional multi-electrode array for multi-site stimulation and recording in acute brain slices

MO Heuschkel, M Fejtl, M Raggenbass… - Journal of neuroscience …, 2002 - Elsevier
Several multi-electrode array devices integrating planar metal electrodes were designed in
the past 30 years for extracellular stimulation and recording from cultured neuronal cells and …