Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options

Z Sas, E Cendrowicz, I Weinhäuser… - International Journal of …, 2022 - mdpi.com
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer

MN Amin, SA Siddiqui, M Ibrahim… - SAGE open …, 2020 - journals.sagepub.com
Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low
molecular weight secreted by different cell types. They regulate intercellular communication …

Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

V Raman, N Van Dessel, CL Hall, VE Wetherby… - Nature …, 2021 - nature.com
Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell
membranes. Here we report the development of a Salmonella-based intracellular delivery …

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

K Mahmoud, S Swidan, M El-Nabarawi… - Journal of …, 2022 - Springer
Liver cancer is considered one of the deadliest diseases with one of the highest disease
burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is …

Antioxidant role of kaempferol in prevention of hepatocellular carcinoma

N Sharma, S Biswas, N Al-Dayan, AS Alhegaili… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are noxious to cells because their increased level interacts
with the body's defense mechanism. These species also cause mutations and uncontrolled …

Radiation-induced liver disease: current understanding and future perspectives

J Kim, Y Jung - Experimental & molecular medicine, 2017 - nature.com
Although radiotherapy (RT) is used for the treatment of cancers, including liver cancer,
radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation …

Radiomics on gadoxetic acid–enhanced magnetic resonance imaging for prediction of postoperative early and late recurrence of single hepatocellular carcinoma

S Kim, J Shin, DY Kim, GH Choi, MJ Kim, JY Choi - Clinical Cancer Research, 2019 - AACR
Purpose: To evaluate the usefulness of the radiomic model in predicting early (≤ 2 years)
and late (> 2 years) recurrence after curative resection in cases involving a single …

Viral oncology: molecular biology and pathogenesis

UN Mui, CT Haley, SK Tyring - Journal of clinical medicine, 2017 - mdpi.com
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of
the world's population harbors at least one of these oncoviruses, but only a small proportion …

Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma

V Chew, YH Lee, L Pan, NJM Nasir, CJ Lim, C Chua… - Gut, 2019 - gut.bmj.com
Objectives Yttrium-90 (Y90)-radioembolisation (RE) significantly regresses locally advanced
hepatocellular carcinoma and delays disease progression. The current study is designed to …

Therapeutic options in hepatocellular carcinoma: a comprehensive review

D Suresh, AN Srinivas, A Prashant… - Clinical and …, 2023 - Springer
Hepatocellular carcinoma (HCC) is a chronic liver disease that is highly fatal if not detected
and treated early. The incidence and death rate of HCC have been increasing in recent …