Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

Synapses are highly plastic and are modified by changes in patterns of neural activity or
sensory experience. Plasticity of cortical excitatory synapses is thought to be important for …

Humans and many other animals have an enormous capacity to learn about sensory stimuli
and to master new skills. However, many of the mechanisms that enable us to learn remain …

Recognition of objects from sensory stimuli is essential for survival. To that end, sensory
networks in the brain must form object representations invariant to stimulus changes, such …

Plasticity of cortical responses in vivo involves activity-dependent changes at synapses, but
the manner in which different forms of synaptic plasticity act together to create functional …

Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic
homeostasis hypothesis suggests that synaptic connections are strengthened during wake …

The cerebral cortex is plastic and represents the world according to the significance of
sensory stimuli. However, cortical networks are embodied in complex circuits, including …

INTRODUCTION Opportunities and dangers can often be predicted on the basis of sensory
clues. The attack of a predator, for example, may be preceded by the sounds of breaking …

The computational repertoire of neurons is enhanced by regenerative electrical signals
initiated in dendrites. These events, referred to as dendritic spikes, can act as cell-intrinsic …

The cerebral cortex integrates sensory information with emotional states and internal
representations to produce coherent percepts, form associations, and execute voluntary …