Ceftolozane-tazobactam against Pseudomonas aeruginosa cystic fibrosis clinical isolates in the hollow-fiber infection model: challenges imposed by hypermutability …
Pseudomonas aeruginosa remains a challenge in chronic respiratory infections in cystic
fibrosis (CF). Ceftolozane-tazobactam has not yet been evaluated against multidrug …
fibrosis (CF). Ceftolozane-tazobactam has not yet been evaluated against multidrug …
Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with β-Lactam/β-Lactamase Inhibitor Combinations against Pseudomonas aeruginosa
DM Ramirez, D Ramirez, S Dhiman… - ACS Infectious …, 2023 - ACS Publications
Carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa) was designated as a
critical priority pathogen by the World Health Organization for which new therapeutic …
critical priority pathogen by the World Health Organization for which new therapeutic …
Simulated intravenous versus inhaled tobramycin with or without intravenous ceftazidime evaluated against hypermutable Pseudomonas aeruginosa via a dynamic …
Acute exacerbations of chronic respiratory infections in patients with cystic fibrosis are highly
challenging due to hypermutable Pseudomonas aeruginosa, biofilm formation and …
challenging due to hypermutable Pseudomonas aeruginosa, biofilm formation and …
Using host-mimicking conditions and a murine cutaneous abscess model to identify synergistic antibiotic combinations effective against Pseudomonas aeruginosa
N Lyons, W Wu, Y Jin, IL Lamont… - Frontiers in Cellular and …, 2024 - frontiersin.org
Antibiotic drug combination therapy is critical for the successful treatment of infections
caused by multidrug resistant pathogens. We investigated the efficacy of β-lactam and β …
caused by multidrug resistant pathogens. We investigated the efficacy of β-lactam and β …
Penicillin G concentrations required for prophylaxis against Group A Streptococcus infection evaluated using a hollow fibre model and mathematical modelling
Background Acute rheumatic fever (ARF), an autoimmune reaction to Group A
Streptococcus (Streptococcus pyogenes; Strep A) infection, can cause rheumatic heart …
Streptococcus (Streptococcus pyogenes; Strep A) infection, can cause rheumatic heart …
Ceftazidime/Tobramycin Co-Loaded Chitosan-Coated Zein Nanoparticles against Antibiotic-Resistant and Biofilm-Producing Pseudomonas aeruginosa and …
LAA Campos, AFS Neto, AML Scavuzzi, ACDS Lopes… - Pharmaceuticals, 2024 - mdpi.com
This study aimed to co-encapsulate ceftazidime and tobramycin in zein nanoparticles coated
with chitosan and to characterize and evaluate the antibacterial and antibiofilm activity …
with chitosan and to characterize and evaluate the antibacterial and antibiofilm activity …
Enhancing bactericidal activities of ciprofloxacin by targeting the trans-translation system that is involved in stress responses in Klebsiella pneumoniae
W Fang, J Xu, Z Wei, J Wu, W Wu, Y Wang… - Archives of …, 2024 - Springer
Although the trans-translation system is a promising target for antcibiotic development, its
antibacterial mechanism in Klebsiella pneumoniae (KP) is unclear. Considering that tmRNA …
antibacterial mechanism in Klebsiella pneumoniae (KP) is unclear. Considering that tmRNA …
Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the …
We evaluated piperacillin-tazobactam and tobramycin regimens against Pseudomonas
aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) …
aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) …