Gastroesophageal reflux disease (GERD) continues to be among the most common
diseases seen by gastroenterologists, surgeons, and primary care physicians. Our …

Cerebral palsy (CP) is the most prevalent, severe and costly motor disability of childhood.
Consequently, CP is a public health priority for prevention, but its aetiology has proved …

The Magic of Randomization Nonrandomized observational analyses have been promoted
as alternatives to randomized clinical trials. However, randomization ensures balance …

Background Researchers and organizations often use evidence from randomized controlled
trials (RCTs) to determine the efficacy of a treatment or intervention under ideal conditions …

Many paediatric clinical research studies, whether observational or interventional, have as
an eventual aim the identification or quantification of causal relationships. One might ask …

Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing
tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with …

This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …

Corticosteroids are administered in pregnancy for their immunosuppressive and
antiinflammatory effects. 1 They are used to treat symptoms of autoimmune conditions …

Objective To evaluate the safety of benzodiazepines and opioids in patients with very severe
chronic obstructive pulmonary disease (COPD). Design Population based longitudinal …

Background Accumulating evidence suggests that statins affect diseases other than
cardiovascular disease, including cancer, and that these effects may depend on the lipid …