The gastrointestinal (GI) tract is innervated by intrinsic enteric neurons and by extrinsic
efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of …

Neurotrophins are powerful molecules. Small quantities of these secreted proteins exert
robust effects on neuronal survival, synapse stabilization, and synaptic function. Key …

Bone is richly innervated by nerve growth factor–responsive (NGF-responsive) tropomyosin
receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required …

Pain is a central feature of soft tissue trauma, which under certain contexts, results in
aberrant osteochondral differentiation of tissue-specific stem cells. Here, the role of sensory …

Developing tissues dictate the amount and type of innervation they require by secreting
neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase …

Sensory nerves emanating from the dorsal root extensively innervate the surfaces of
mammalian bone, a privileged location for the regulation of biomechanical signaling. Here …

The patterning and ossification of the mammalian skeleton requires the coordinated actions
of both intrinsic bone morphogens and extrinsic neurovascular signals, which function in a …

Peripheral neurons terminate at the surface of tendons partly to relay nociceptive pain
signals; however, the role of peripheral nerves in tendon injury and repair remains unclear …

The flat bones of the skull are densely innervated during development, but little is known
regarding their role during repair. We describe a neurotrophic mechanism that directs …

Actin‐based remodelling underlies spine structural changes occurring during synaptic
plasticity, the process that constantly reshapes the circuitry of the adult brain in response to …