Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration

D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

[HTML][HTML] Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ …

Z He, X Li, Z Wang, Y Cao, S Han, N Li, J Cai, S Cheng… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the
deposition of β-amyloid (Aβ) peptides and dysfunction of mitochondrion, which result in …

[HTML][HTML] CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model …

G Ates, J Goldberg, A Currais, P Maher - Redox Biology, 2020 - Elsevier
The oxidative degradation of lipids has been shown to be implicated in the progression of
several neurodegenerative diseases and modulating lipid peroxidation may be efficacious …

Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling

P Ježek, B Holendová, KD Garlid… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

Mast cell activation in brain injury, stress, and post-traumatic stress disorder and Alzheimer's disease pathogenesis

D Kempuraj, GP Selvakumar, R Thangavel… - Frontiers in …, 2017 - frontiersin.org
Mast cells are localized throughout the body and mediate allergic, immune, and
inflammatory reactions. They are heterogeneous, tissue-resident, long-lived, and granulated …

Co-localization of glia maturation factor with NLRP3 inflammasome and autophagosome markers in human Alzheimer's disease brain

ME Ahmed, S Iyer, R Thangavel… - Journal of …, 2017 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
presence of intracellular neurofibrillary tangles (NFTs) containing hyperphosphorylated tau …

[HTML][HTML] Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder

R Kumar, T Amruthanjali, S Singothu, SB Singh… - Biomedicine & …, 2022 - Elsevier
Mitochondrial uncoupling proteins (UCP) are a part of the large family of mitochondrial
solute carriers (SLC25s), concentrated in the inner mitochondrial membrane that carries …

Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders

D Kempuraj, KD Dourvetakis, J Cohen… - Frontiers in Cellular …, 2024 - frontiersin.org
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage
plays a critical role in neurodegenerative diseases. Though the exact mechanism of disease …

Targeted gene editing of glia maturation factor in microglia: a novel Alzheimer's disease therapeutic target

SP Raikwar, R Thangavel, I Dubova… - Molecular …, 2019 - Springer
Alzheimer's disease (AD) is a devastating, progressive neurodegenerative disorder that
leads to severe cognitive impairment in elderly patients. Chronic neuroinflammation plays …