The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Proteinuria is a major health-care problem that affects several hundred million people
worldwide. Proteinuria is a cardinal sign and a prognostic marker of kidney disease, and …

Background Focal segmental glomerulosclerosis is a kidney disease that is manifested as
the nephrotic syndrome. It is often resistant to glucocorticoid therapy and progresses to end …

Podocytes are specialized epithelial cells that cover the outer surfaces of glomerular
capillaries. Unique cell junctions, known as slit diaphragms, which feature nephrin and …

Association testing of multiple correlated phenotypes offers better power than univariate
analysis of single traits. We analyzed 6,600 individuals from two population-based cohorts …

Myosin-I molecular motors are proposed to play various cellular roles related to membrane
dynamics and trafficking. In this Cell Science at a Glance article and the accompanying …

Podocytes are specialized cells that play an integral role in the renal glomerular filtration
barrier via their foot processes. The foot processes form a highly organized structure, the …

Class 1 myosins are small motor proteins with the ability to simultaneously bind to actin
filaments and cellular membranes. Given their ability to generate mechanical force, and their …

Unconventional myosins are proteins that bind actin filaments in an ATP-regulated manner.
Because of their association with membranes, they have traditionally been viewed as motors …