The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

Failure of regulatory T (Treg) cells to properly control immune responses leads invariably to
autoimmunity and organ damage. Decreased numbers or impaired function of Treg cells …

CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

Depletion of regulatory T (TReg) cells in otherwise healthy individuals leads to multi-organ
autoimmune disease and inflammation. This indicates that in a normal immune system …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …

Regulatory T (Treg) cells are crucial for peripheral immune tolerance and prevention of
autoimmunity and tissue damage. Treg cells are inherently defined by the expression of the …

Foxp3+ regulatory T cells (Treg cells) are required for immunological homeostasis. One
notable distinction between conventional T cells (Tconv cells) and Treg cells is differences in …

Abstract The PI3K/AKT signaling pathway is an essential node in mammalian cells that
controls cell growth, migration, proliferation, and metabolism. During the last decade, a …