From NASH to HCC: current concepts and future challenges

QM Anstee, HL Reeves, E Kotsiliti, O Govaere… - Nature reviews …, 2019 - nature.com
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

Obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma: Current status and therapeutic targets

Y Chen, W Wang, MP Morgan, T Robson… - Frontiers in …, 2023 - frontiersin.org
Obesity is a global epidemic and overwhelming evidence indicates that it is a risk factor for
numerous cancers, including hepatocellular carcinoma (HCC), the third leading cause of …

Transcriptional regulation in non-alcoholic fatty liver disease

S Steensels, J Qiao, BA Ersoy - Metabolites, 2020 - mdpi.com
Obesity is the primary risk factor for the pathogenesis of non-alcoholic fatty liver disease
(NAFLD), the worldwide prevalence of which continues to increase dramatically. The liver …

[HTML][HTML] Animal models of NAFLD from the pathologist's point of view

H Denk, PM Abuja, K Zatloukal - … et Biophysica Acta (BBA)-Molecular Basis …, 2019 - Elsevier
Fatty liver disease is a multifactorial world-wide health problem resulting from a complex
interplay between liver, adipose tissue and intestine and initiated by alcohol abuse …

Hyperlipidemia may synergize with hypomethylation in establishing trained immunity and promoting inflammation in NASH and NAFLD

CIV Drummer, F Saaoud, Y Sun, D Atar… - Journal of …, 2021 - Wiley Online Library
We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH)
microarray data and microarray/RNA‐seq data from various mouse models of nonalcoholic …

[HTML][HTML] Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats

SH Gou, HF Huang, XY Chen, J Liu, M He… - Journal of the Chinese …, 2016 - Elsevier
Background Hyperlipidemia and its complications are among the most harmful of diseases
with a worldwide impact, which creates an urgent imperative to find safe and effective drugs …

[HTML][HTML] Baicalin attenuates diet induced nonalcoholic steatohepatitis by inhibiting inflammation and oxidative stress via suppressing JNK signaling pathways

X Zhong, H Liu - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Nonalcoholic steatohepatitis may develop into hepatic cirrhosis. The therapeutic drugs for
NASH are absent. Baicalin (BC) has hepatoprotective effect, while whether BC could …

Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation

Q Meng, X Duan, C Wang, Z Liu, P Sun… - Acta Pharmacologica …, 2017 - nature.com
Abstract Alisol B 23-acetate (AB23A) is a natural triterpenoid isolated from the traditional
Chinese medicine rhizoma alismatis, which exhibits a number of pharmacological activities …

Activation of FXR modulates SOCS3/Jak2/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model

YM Attia, RA Tawfiq, AA Gibriel, AA Ali… - Biochemical …, 2021 - Elsevier
Despite the recent substantial progress in the treatment of hepatocellular carcinoma (HCC)
from viral etiology, non-alcoholic steatohepatitis (NASH) is on a trajectory to become the …

Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice

C Wang, X Duan, X Sun, Z Liu, P Sun, X Yang, H Sun… - Food & function, 2016 - pubs.rsc.org
Non-alcoholic steatohepatitis (NASH) is a syndrome with simultaneous severe hepatic
steatosis, lobular inflammation and pericelluar fibrosis. The purpose of the present study is …