Lentiviral vectors for use in the central nervous system

J Jakobsson, C Lundberg - Molecular Therapy, 2006 - cell.com
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous
system throughout the past decade since they transduce most cell types in the brain …

Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord

WTJ Hendriks, MJ Ruitenberg, B Blits, GJ Boer… - Progress in brain …, 2004 - Elsevier
Injuries to the adult mammalian spinal cord often lead to severe damage to both ascending
(sensory) pathways and descending (motor) nerve pathways without the perspective of …

Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways

M Vroemen, L Aigner, J Winkler… - European journal of …, 2003 - Wiley Online Library
The main rationale for cell‐based therapies following spinal cord injury are:(i) replacement
of degenerated spinal cord parenchyma by an axon growth supporting scaffold;(ii) …

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

U Englund, A Björklund, K Wictorin… - Proceedings of the …, 2002 - National Acad Sciences
In vitro expanded neural stem/progenitor cells can undergo region-specific differentiation
after transplantation to the developing or adult brain, and display morphologies and markers …

[HTML][HTML] Role of bone morphogenetic protein-2 in osteogenic differentiation of mesenchymal stem cells

J Sun, J Li, C Li, Y Yu - Molecular medicine reports, 2015 - spandidos-publications.com
Bone mesenchymal stem cells (BMSCs) have been an area of interest in biomedical
research and tissue engineering due to their diverse differentiation abilities. In osteogenesis …

Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections

U Englund, RA Fricker-Gates, C Lundberg… - Experimental …, 2002 - Elsevier
Here we examined the ability of human neural progenitors from the embryonic forebrain,
expanded for up to a year in culture in the presence of growth factors, to respond to …

Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain

U Englund, A Björklund, K Wictorin - Developmental Brain Research, 2002 - Elsevier
We have examined long-term growth-factor expanded human neural progenitors following
transplantation into the adult rat brain. Cells, obtained from the forebrain of a 9-week old …

In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins

Y Kang, CS Stein, JA Heth, PL Sinn… - Journal of …, 2002 - Am Soc Microbiol
Vectors derived from lentiviruses provide a promising gene delivery system. We examined
the in vivo gene transfer efficiency and tissue or cell tropism of a feline immunodeficiency …

Enhancement of magnetic nanoparticle-mediated gene transfer to astrocytes by 'magnetofection': effects of static and oscillating fields

M Pickard, D Chari - Nanomedicine, 2010 - Taylor & Francis
Aims: To assess the feasibility of using magnetic nanoparticles (MNPs) to transfect
astrocytes derived for transplantation and determine if transfection efficacy can be enhanced …

An antiaggregation gene therapy strategy for Lewy body disease utilizing β-synuclein lentivirus in a transgenic model

M Hashimoto, E Rockenstein, M Mante, L Crews… - Gene therapy, 2004 - nature.com
Current experimental gene therapy approaches for Parkinson's disease (PD) and dementia
with Lewy bodies (DLB) include the use of viral vectors expressing antiapoptosis genes …