The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19

Y Xu, DJ Baylink, CS Chen, ME Reeves, J Xiao… - Journal of translational …, 2020 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a
Public Health Emergency of International Concern by the World Health Organization. As of …

Targeting LSD1 for acute myeloid leukemia (AML) treatment

S Zhang, M Liu, Y Yao, B Yu, H Liu - Pharmacological research, 2021 - Elsevier
Targeted therapy for acute myeloid leukemia (AML) is an effective strategy, but currently
there are very limited therapeutic targets for AML treatment. Histone lysine specific …

[HTML][HTML] Vitamin D effects on cell differentiation and stemness in cancer

A Fernández-Barral, P Bustamante-Madrid… - Cancers, 2020 - mdpi.com
Vitamin D 3 is the precursor of 1α, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), a pleiotropic
hormone that is a major regulator of the human genome. 1, 25 (OH) 2 D 3 modulates the …

Analysis of serum cytokine and protective vitamin D levels in severe cases of COVID‐19

N Bayraktar, H Turan, M Bayraktar… - Journal of medical …, 2022 - Wiley Online Library
In this study, we investigated the role and relationship between the cytokine profile and
protective vitamin D by measuring their serum levels in COVID‐19 intensive care unit …

Vitamin D receptor controls cell stemness in acute myeloid leukemia and in normal bone marrow

E Paubelle, F Zylbersztejn, TT Maciel, C Carvalho… - Cell reports, 2020 - cell.com
Vitamin D (VD) is a known differentiating agent, but the role of VD receptor (VDR) is still
incompletely described in acute myeloid leukemia (AML), whose treatment is based mostly …

Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-β activity

C Ricca, A Aillon, M Viano, L Bergandi, E Aldieri… - The Journal of Steroid …, 2019 - Elsevier
Vitamin D and TGF-β exert opposite effects on epithelial-mesenchymal EMT transition. Here
we report a novel mechanism of action of TGF-β that promotes the counteracting activity of …

[HTML][HTML] Calcitriol inhibits proliferation and potentially induces apoptosis in B16–F10 cells

EK Sutedja, D Amarassaphira… - Medical Science …, 2022 - ncbi.nlm.nih.gov
Background Melanoma is one of the most aggressive types of cancer and it has shown a
remarkable surge in incidence during the last 50 years. Melanoma has been projected to be …

Vitamin C and D supplementation in acute myeloid leukemia

PL Mouchel, E Bérard, S Tavitian, N Gadaud… - Blood …, 2023 - ashpublications.org
Recent studies have highlighted the role of vitamin C and D in acute myeloid leukemia
(AML). In 2018, we changed our practices to add both vitamins to the supportive care for all …

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

C Ruggiero, L Tafaro, L Cianferotti, F Tramontana… - Nutrients, 2024 - mdpi.com
Aging is the result of several complex and multifactorial processes, where several agents
contribute to an increased intrinsic vulnerability and susceptibility to age-related diseases …

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a …

M Nachliely, A Trachtenberg, B Khalfin… - The Journal of steroid …, 2019 - Elsevier
Acute myeloid leukemia (AML) is one of the deadliest hematological malignancies without
effective treatment for most patients. Vitamin D derivatives (VDDs)-active metabolites 1α, 25 …