The chronic mild stress (CMS) model of depression has high validity but has in the past
been criticized for being difficult to replicate. However, a large number of recent publications …

This review gives an overview of recent findings and developments in research on brain
mechanisms of reward and reinforcement from studies using the place preference …

The chronic mild stress (CMS) model of depression is considered by many to be the animal
model of depression that has the greatest validity and translational potential, but it has often …

In order to develop a model for a depression-like syndrome in mice, we subjected male
C57BL/6 mice to a 4-week-long chronic stress procedure, consisting of rat exposure …

The present paper reviews evidence on the effect of antidepressant treatments on dopamine
transmission. Chronic treatment with antidepressant drugs potentiates the behavioural …

The goal of this review is to familiarize the reader about the potential involvement of the
brain reward system (BRS) in symptoms of Major Depressive Disorder (MDD). The authors …

Rationale Many studies support the validity of the chronic mild stress (CMS) model of
depression in rodents. However, most of them focus on analysis of reactivity to rewards …

The chronic mild stress (CMS) paradigm was developed in order to simulate in animals the
symptom of anhedonia, a major feature of depression. Typically, changes in hedonic status …

The NIH Consensus Development Conference1 concluded that treatment with
antidepressants is effective in reducing symptoms and signs of geriatric depression …

Clinical studies have not yet determined a common mechanism of action for antidepressant
drugs, which have primary sites of action on a variety of different neurotransmitter systems …