Mechanism of action of ribosomally synthesized and post-translationally modified peptides
C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …
product class that has undergone significant expansion due to the rapid growth in genome …
New developments in RiPP discovery, enzymology and engineering
M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
The RaPID platform for the discovery of pseudo-natural macrocyclic peptides
Y Goto, H Suga - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Although macrocyclic peptides bearing exotic building blocks have proven their
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …
[HTML][HTML] Marine natural products: A source of novel anticancer drugs
Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new
drugs with novel modes of action and thus considerable research has been conducted for …
drugs with novel modes of action and thus considerable research has been conducted for …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
[HTML][HTML] The evolution of genome mining in microbes–a review
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
[HTML][HTML] Natural products from cyanobacteria: Focus on beneficial activities
Cyanobacteria are photosynthetic microorganisms that colonize diverse environments
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …
[HTML][HTML] A roadmap for metagenomic enzyme discovery
SL Robinson, J Piel, S Sunagawa - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Covering: 1988 to 2012 This review presents recommended nomenclature for the
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …
Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing
The cyanobacterial phylum encompasses oxygenic photosynthetic prokaryotes of a great
breadth of morphologies and ecologies; they play key roles in global carbon and nitrogen …
breadth of morphologies and ecologies; they play key roles in global carbon and nitrogen …