Advances in epigenetics link genetics to the environment and disease
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
Epigenetics, DNA damage, and aging
C Soto-Palma, LJ Niedernhofer… - The Journal of …, 2022 - Am Soc Clin Investig
Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …
abundance of several types of chromatin changes. The abundance of DNA lesions …
Genomic imprinting and physiological processes in mammals
Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …
chromosomes per nucleus, combining the genetic material of both parents. However …
Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
DNA methylation reprogramming during mammalian development
Y Zeng, T Chen - Genes, 2019 - mdpi.com
DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
Single-cell RNA-seq analysis maps development of human germline cells and gonadal niche interactions
Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for
maintenance of the species. However, the developmental trajectories and heterogeneity of …
maintenance of the species. However, the developmental trajectories and heterogeneity of …
Gestational diabetes mellitus and macrosomia: a literature review
K Kc, S Shakya, H Zhang - Annals of Nutrition and Metabolism, 2015 - karger.com
Background: Fetal macrosomia, defined as a birth weight≥ 4,000 g, may affect 12% of
newborns of normal women and 15-45% of newborns of women with gestational diabetes …
newborns of normal women and 15-45% of newborns of women with gestational diabetes …
Characterizing mutagenic effects of recombination through a sequence-level genetic map
INTRODUCTION Diversity in the sequence of the human genome, arising from
recombinations and mutations, is fundamental to human evolution and human diversity …
recombinations and mutations, is fundamental to human evolution and human diversity …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …