Since the initial clinical approval in the late 1990s and remarkable anticancer effects for
certain types of cancer, molecular targeted therapy utilizing small molecule agents or …

Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

PURPOSE To provide real-world evidence on risks and outcomes of breakthrough COVID-
19 infections in vaccinated patients with cancer using the largest national cohort of COVID …

Less than a year since the start of the COVID-19 pandemic, ten vaccines against SARS-CoV-
2 have been approved for at least limited use, with over sixty others in clinical trials. This …

Deregulation of the cyclin D‐CDK4/6‐INK4‐RB pathway leading to uncontrolled cell
proliferation, is frequently observed in breast cancer. Currently, three selective CDK4/6 …

Breast cancer has an extremely high incidence in women, and its morbidity and mortality
rank first among female tumors. With the increasing development of medicine today, the …

The progress in the development of various vaccine platforms against SARS-CoV-2 have
been rather remarkable owing to advancement in molecular and biologic sciences. Most of …

Neddylation is a sequential enzyme-based process which regulates the function of E3 Cullin-
RING ligase (CRL) and thus degradation of substrate proteins. Here we show that CD8+ T …

Background Epidermal growth factor receptor (EGFR) is frequently amplified or
overexpressed in head and neck squamous cell carcinoma (HNSCC) and is a clinically …