Tubulin, an important clinical molecular target, has attracted high attention in drug design
development and cancer treatment. Tubulin inhibitors cause cell cycle arrest in the G 2/M …

Harvesting sunlight to drive carbon dioxide (CO2) valorisation represents an ideal concept
to support a sustainable and carbon-neutral economy. While the photochemical reduction of …

Abstract Combretastatin A-4 (CA-4) is a natural anti-cancer agent isolated in 1989 from the
African willow tree, Combretum caffrum. Due to its chemical simplicity, this (Z)-stilbene has …

Two series of structurally related organoselenium compounds designed by fusing the
anticancer agent methyl (phenyl) selane into the tubulin polymerization inhibitors iso …

Numerous prodrugs have been developed and used for cancer treatments to reduce side
effects and promote efficacy. In this work, we have developed a new photoactivatable …

The cytotoxic activity of a series of 23 new isoerianin derivatives with modifications on both
the A and B rings was studied. Several compounds exhibited excellent antiproliferative …

A series of quinoline and quinazoline analogs were designed and synthesized as new
tubulin polymerization (TP) and histone deacetylases (HDAC) inhibitors. Compounds 12a …

Designing multitarget drugs have raised considerable interest due to their advantages in the
treatment of complex diseases such as cancer. Their design constitutes a challenge in …

Installation of a boron functionality into a more substituted carbon of terminal alkynes has
been a challenging issue in chemical synthesis, since inherently Lewis acidic boron …

The synthesis and evaluation of a new series of IsoCombretaQuinolines (IsoCoQuines) 2
with a 2-substituted-quinoline in place of the 3, 4, 5-trimethoxyphenyl ring present in isoCA-4 …