Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …

Thymically derived Foxp3+ regulatory T cells (tTregs) constitute a unique T cell lineage that
is essential for maintaining immune tolerance to self and immune homeostasis. However …

Dendritic cells (DCs) are the key professional antigen-presenting cells which bridge innate
and adaptive immune responses, inducing the priming and differentiation of naive to effector …

MicroRNAs (miRs) regulate gene expression at the posttranscriptional level and play crucial
roles in vascular integrity. As such, they may have a role in modifying abdominal aortic …

Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in
immunological self-tolerance, which leads to aberrant immune responses against …

Foxp3+ T regulatory cells (Tregs) consisting of natural and induced Treg subsets play a
crucial role in the maintenance of immune homeostasis against self-antigen. The actions …

In vitro data and transgenic mouse models suggest a role for TGF-β signaling in dendritic
cells (DCs) to prevent autoimmunity primarily through maintenance of DCs in their immature …

Abstract Objective Transferred CD4+ CD25+ FoxP3+ Treg cells can prevent autoimmune
disease, but generally fail to ameliorate established disease. This study was undertaken to …

Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg)
cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell …

Regulatory T cells play important roles in cancer development and progression by limiting
the generation of innate and adaptive anti-tumor immunity. We hypothesized that in addition …