From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
Cannabis in cancer care
DI Abrams, M Guzman - Clinical Pharmacology & Therapeutics, 2015 - Wiley Online Library
Cannabis has been used in medicine for thousands of years prior to achieving its current
illicit substance status. Cannabinoids, the active components of Cannabis sativa, mimic the …
illicit substance status. Cannabinoids, the active components of Cannabis sativa, mimic the …
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin
RG Pertwee - British journal of pharmacology, 2008 - Wiley Online Library
Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …
The endocannabinoid system as an emerging target of pharmacotherapy
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …
triggered an exponential growth of studies exploring the endocannabinoid system and its …
Modulating the endocannabinoid system in human health and disease–successes and failures
The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …
Towards the use of cannabinoids as antitumour agents
Various reports have shown that cannabinoids (the active components of marijuana and
their derivatives) can reduce tumour growth and progression in animal models of cancer, in …
their derivatives) can reduce tumour growth and progression in animal models of cancer, in …
Cannabinoids as novel anti-inflammatory drugs
P Nagarkatti, R Pandey, SA Rieder… - Future medicinal …, 2009 - Taylor & Francis
Cannabinoids are a group of compounds that mediate their effects through cannabinoid
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …
The endocannabinoid system and its therapeutic exploitation
The term'endocannabinoid'—originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …
Is lipid signaling through cannabinoid 2 receptors part of a protective system?
P Pacher, R Mechoulam - Progress in lipid research, 2011 - Elsevier
The mammalian body has a highly developed immune system which guards against
continuous invading protein attacks and aims at preventing, attenuating or repairing the …
continuous invading protein attacks and aims at preventing, attenuating or repairing the …
Cannabinoids: potential anticancer agents
M Guzman - Nature reviews cancer, 2003 - nature.com
Cannabinoids—the active components of Cannabis sativa and their derivatives—exert
palliative effects in cancer patients by preventing nausea, vomiting and pain and by …
palliative effects in cancer patients by preventing nausea, vomiting and pain and by …