Fat is stored in distinct depots with unique features in both mice and humans and B cells
reside in all adipose depots. We have shown that B cells modulate cardiometabolic disease …

Inflammation represents a fundamental immune response triggered by various detrimental
stimuli, such as infections, tissue damage, toxins, and foreign substances. Protein …

Background: Atherosclerosis (AS) is still the major cause of cardiovascular disease (CVD)
as well as stroke. Endothelial metabolic disorder has been found to be activated and then …

Circulating CD11c+ B cells, a novel subset of activated B cells, have been linked to
autoimmunity and shown to expand with age. Atherosclerosis is an age-associated disease …

Atherosclerosis (AS) is a chronic inflammatory disease that is a major cause of
cardiovascular diseases (CVDs), including coronary artery disease, hypertension …

In the genesis and progression of cardiovascular diseases involving both innate and
adaptive immune responses, inflammation plays a pivotal and dual role. Studies in …

Lipid metabolism disorder is the basis of atherosclerotic lesions, in which cholesterol and
low-density lipoprotein (LDL) is the main factor involved with the atherosclerotic …

In recent years, in addition to the well-established role of T cells in controlling or promoting
tumor growth, a new wave of research has demonstrated the active involvement of B cells in …

Immunoglobulin M (IgM) to oxidation specific epitopes (OSE) are inversely associated with
atherosclerosis in mice and humans. The B-1b subtype of B-1 cells secrete IgM to OSE, and …

Recent studies have demonstrated a role for Ten-Eleven Translocation-2 (TET2), an
epigenetic modulator, in regulating germinal center formation and plasma cell differentiation …