Looping the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
Best practices for the visualization, mapping, and manipulation of R‐loops
R‐loops represent an abundant class of large non‐B DNA structures in genomes. Even
though they form transiently and at modest frequencies, interfering with R‐loop formation or …
though they form transiently and at modest frequencies, interfering with R‐loop formation or …
PARP1 associates with R-loops to promote their resolution and genome stability
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …
Genome-wide mapping reveals R-loops associated with centromeric repeats in maize
Y Liu, Q Liu, H Su, K Liu, X Xiao, W Li, Q Sun… - Genome …, 2021 - genome.cshlp.org
R-loops are stable chromatin structures comprising a DNA: RNA hybrid and a displaced
single-stranded DNA. R-loops have been implicated in gene expression and chromatin …
single-stranded DNA. R-loops have been implicated in gene expression and chromatin …
A cohesin traffic pattern genetically linked to gene regulation
Cohesin-mediated loop extrusion has been shown to be blocked at specific cis-elements,
including CTCF sites, producing patterns of loops and domain boundaries along …
including CTCF sites, producing patterns of loops and domain boundaries along …
Full circle: a brief history of cohesin and the regulation of gene expression
JA Horsfield - The FEBS journal, 2023 - Wiley Online Library
The cohesin complex has a range of crucial functions in the cell. Cohesin is essential for
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …
EWSR1 maintains centromere identity
The centromere is essential for ensuring high-fidelity transmission of chromosomes. CENP-
A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere …
A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere …
Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair
Y Wang, B Gao, L Zhang, X Wang, X Zhu… - Nature …, 2024 - nature.com
Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but
resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a …
resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a …
[HTML][HTML] DeepMC-iNABP: Deep learning for multiclass identification and classification of nucleic acid-binding proteins
Nucleic acid-binding proteins (NABPs), including DNA-binding proteins (DBPs) and RNA-
binding proteins (RBPs), play vital roles in gene expression. Accurate identification of these …
binding proteins (RBPs), play vital roles in gene expression. Accurate identification of these …