IgH class switching occurs rapidly after activation of mature naive B cells, resulting in a
switch from expression of IgM and IgD to expression of IgG, IgE, or IgA; this switch improves …

Upon encountering antigens, mature IgM-positive B lymphocytes undergo class-switch
recombination (CSR) wherein exons encoding the default Cμ constant coding gene …

Increasing evidence suggests that interactions between regulatory genomic elements play
an important role in regulating gene expression. We generated a genome-wide interaction …

The B cell receptor (BCR) is expressed on the B lymphocyte cell surface where it serves as a
receptor for foreign antigens (1). The BCR is comprised of two immunoglobulin (Ig) heavy …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Females and males differ in antibody isotype expression patterns and in immune responses
to foreign-and self-antigens. For example, systemic lupus erythematosus is a condition that …

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-
coupled recruitment of activation-induced cytidine deaminase (AID) to switch regions and by …

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-
coupled recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S …

Antibody class switch recombination (CSR) in B lymphocytes joins two DNA double-strand
breaks (DSBs) lying 100–200 kb apart within switch (S) regions in the immunoglobulin …

The G4 motif, G≥ 3NxG≥ 3NxG≥ 3NxG≥ 3, is enriched in some genomic regions and
depleted in others. This motif confers the ability to form an unusual four‐stranded DNA …