Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …

Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor
of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes …

Understanding the molecular events that regulate osteoblast differentiation is essential for
the development of effective approaches to bone regeneration. In this study, we analysed …

Simple Summary Solid tumors such as prostate, breast, and lung cancers frequently spread
to bone, causing severe pain, disability, and cancer-related deaths. The multiple types of …

Background Osteoinduction and subsequent bone formation rely on efficient mesenchymal
stem cell (MSC) recruitment. It is also known that migration is induced by gradients of growth …

Phenotypic drug discovery (PDD) continues to fuel the research and development pipelines
with first-in-class therapeutic modalities, but success rates critically depend on the quality of …

Background/Aims: Long noncoding RNAs (lncRNAs) play important roles in stem cell
differentiation. However, their role in osteogenesis of human adipose-derived stem cells …

Heterotopic ossification (HO) is the ectopic bone formation in soft tissues. Aside from
hereditary HO, traumatic HO is common after orthopedic surgery, combat-related injuries …

Excessive glucocorticoid (GC) action is linked to various metabolic disorders. Recent
findings suggest that disrupting skeletal GC signaling prevents bone loss and alleviates …

Circulating exosomes delivering microRNAs are involved in the occurrence and
development of cardiovascular diseases. How are the circulating exosomes involved in the …