BDNF as a promising therapeutic agent in Parkinson's disease

E Palasz, A Wysocka, A Gasiorowska… - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases

KF Azman, R Zakaria - International journal of molecular sciences, 2022 - mdpi.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …

Neurotrophin regulation of neural circuit development and function

H Park, M Poo - Nature Reviews Neuroscience, 2013 - nature.com
Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

Neurobiology of local and intercellular BDNF signaling

M Sasi, B Vignoli, M Canossa, R Blum - Pflügers Archiv-European Journal …, 2017 - Springer
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted
proteins. Signaling cascades induced by BDNF and its receptor, the receptor tyrosine kinase …

Neuronal plasticity and neurotrophic factors in drug responses

E Castrén, H Antila - Molecular psychiatry, 2017 - nature.com
Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

SL Patterson - Neuropharmacology, 2015 - Elsevier
Older individuals often experience declines in cognitive function after events (eg infection, or
injury) that trigger activation of the immune system. This occurs at least in part because …

proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus

J Yang, LC Harte-Hargrove, CJ Siao, T Marinic… - Cell reports, 2014 - cell.com
Experience-dependent plasticity shapes postnatal development of neural circuits, but the
mechanisms that refine dendritic arbors, remodel spines, and impair synaptic activity are …

[HTML][HTML] Brain-derived neurotrophic factor: three ligands, many actions

BL Hempstead - Transactions of the American Clinical and …, 2015 - ncbi.nlm.nih.gov
Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which
include nerve growth factor, neurotrophin 3, and neurotrophin 4. Studies over the last three …

The effect of insomnia on development of Alzheimer's disease

S Sadeghmousavi, M Eskian, F Rahmani… - Journal of …, 2020 - Springer
Alzheimer's disease (AD) is the most common type of dementia and a neurodegenerative
disorder characterized by memory deficits especially forgetting recent information, recall …

Mechanisms that modulate and diversify BDNF functions: implications for hippocampal synaptic plasticity

AP De Vincenti, AS Ríos, G Paratcha… - Frontiers in cellular …, 2019 - frontiersin.org
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on
neuronal morphology and synaptic plasticity that underlie hippocampal circuit development …