Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working …

J Thagaard, G Broeckx, DB Page… - The Journal of …, 2023 - Wiley Online Library
The clinical significance of the tumor‐immune interaction in breast cancer is now
established, and tumor‐infiltrating lymphocytes (TILs) have emerged as predictive and …

[HTML][HTML] A review of AI-based radiomics and computational pathology approaches in triple-negative breast cancer: current applications and perspectives

G Corredor, S Bharadwaj, T Pathak… - Clinical Breast …, 2023 - Elsevier
Breast cancer is one of the most common and deadly cancers worldwide. Approximately,
20% of all breast cancers are characterized as triple negative (TNBC). TNBC typically is …

Spatial characterization of tumor-infiltrating lymphocytes and breast cancer progression

DJ Fassler, LA Torre-Healy, R Gupta, AM Hamilton… - Cancers, 2022 - mdpi.com
Simple Summary The assessment of tumor-infiltrating lymphocytes (TILs) is gaining
acceptance as a robust biomarker to help predict prognosis and treatment response. We …

Intratumoral tumor infiltrating lymphocytes (TILs) are associated with cell proliferation and better survival but not always with chemotherapy response in breast cancer

R Wu, M Oshi, M Asaoka, L Yan, MGK Benesch… - Annals of …, 2023 - journals.lww.com
Objective: To investigate the clinical relevance of intratumoral tumor infiltrating lymphocytes
(TILs) in breast cancer as measured by computational deconvolution of bulk tumor …

Incorporation of TILs in daily breast cancer care: how much evidence can we bear?

AV Laenkholm, G Callagy, M Balancin, JMS Bartlett… - Virchows Archiv, 2022 - Springer
One of the most important developments in the breast cancer field has been an improved
understanding of prognostic and predictive biomarkers, of which TILs are increasingly …

ONEST (observers needed to evaluate subjective tests) analysis of stromal tumour-infiltrating lymphocytes (sTILs) in breast cancer and its limitations

B Cserni, D Kilmartin, M O'Loughlin, X Andreu… - Cancers, 2023 - mdpi.com
Simple Summary Tumour-infiltrating lymphocytes (TILs) reflect the host's response against
tumours. TILs have a strong prognostic effect in the so-called triple-negative (oestrogen …

Reproducibility and Feasibility of Classification and National Guidelines for Histological Diagnosis of Canine Mammary Gland Tumours: A Multi-Institutional Ring …

S Papparella, MI Crescio, V Baldassarre, B Brunetti… - Veterinary …, 2022 - mdpi.com
Simple Summary Tumours of the mammary gland are common in humans, as in canine
species. They are very heterogenous with numerous morphological variants and different …

Training pathologists to assess stromal tumour‐infiltrating lymphocytes in breast cancer synergises efforts in clinical care and scientific research

A Ly, V Garcia, KRM Blenman, A Ehinger… - …, 2024 - Wiley Online Library
A growing body of research supports stromal tumour‐infiltrating lymphocyte (TIL) density in
breast cancer to be a robust prognostic and predicive biomarker. The gold standard for …

[HTML][HTML] Prioritizing cases from a multi-institutional cohort for a dataset of pathologist annotations

V Garcia, E Gardecki, S Jou, X Li, KR Shroyer… - Journal of Pathology …, 2025 - Elsevier
Objective With the increasing energy surrounding the development of artificial intelligence
and machine learning (AI/ML) models, the use of the same external validation dataset by …

[PDF][PDF] Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer

J Thagaard, ES Stovgaard, T Papathomas - 2023 - research.birmingham.ac.uk
The prognostic and predictive significance of the tumor-immune interaction in breast cancer
(BC) has been investigated intensively in recent years [1, 2], and tumor-infiltrating …